Among liver and kidney diseases, mycotoxin contamination of feed has become a major concern in animal feed science. A case control study was conducted to evaluate the recovery efficiency of lactic acid bacteria on serum lipid profile parameters and histopathological changes of nephrotoxic and hepatotoxic mycotoxin fumonisin B1 (FB1)-induced toxicity in kidney and liver of rats. Eighteen rats were randomly assigned to 12 experimental groups fed various doses of FB1 and/or co-administrated Lactobacillus delbrueckii subsp. lactis DSM 20076 (LL-DSM) and Pediococcus acidilactici NNRL B-5627 (PA-NNRL) for a period of 28 days. After 2 weeks, no significant signs of toxicity in rats fed FB1 alone or co-administrated with LAB were observed. Treatments of LL-DSM and/or PA-NNRL had no effect on organs weight, lipid profile and histopathological examination of kidney and liver tissues along the experimental period. After 4 weeks, LDL + VLDL cholesterol, TG and TC were significantly increased, however the HDL-C, kidney and liver weights were significantly decreased in animals fed FB1 at doses tested. In the same line, the histopathological examination of livers and kidneys showed a series of morphological alterations in animals fed FB1 especially at the high dose (T200). Administration of LAB resulted in a significant improvement in all treatments tested as well as the histopathological patterns of liver and kidney tissues.
Key words: Histopathology, Lipid profile, Hepatotoxicity, Nephrotoxicity, Fumonisins, LAB, detoxification
|
