The significant findings of the submitted article are optimization of rifampicin dry powder inhalation (DPI) with chitosan-xanthan (CX) as a carrier by spray dry method using response surface methodology (RSM). The entrapment efficiency, particle size, and drug release in pH 7.4 (pulmonary condition) and pH 4.5 (pulmonary macrophages condition) of the rifampicin DPI were output parameters for optimization. The results revealed that the RSM successfully designed an optimum formula of rifampicin DPI at the point of 0.5% CX concentration, the ratio of rifampicin to CX 1:1, and inlet temperature at 143°C.
Key words: chitosan-xanthan, dry powder inhalation, rifampicin, response surface methodology, spray drying.
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