Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles

Open Access

Original Article

AJVS. 2018; 57(1): 148-160

The Potential Ameliorative Effect of Nano-Zinc and Zinc Against Copper Hepatorenal Toxicosis in Rats

Asmaa A. Aboushouk, Samah S. Oda, Samar S. Elblehi.

This study was designed to evaluate the effect of Nano-Zinc (N-Zn) and Zinc (Zn) against copper (Cu) toxicosis in rats. Sixty male albino rats were randomly divided into 6 groups (n=10); control group, Cu-treated group: orally received CuSo4 (100 mg/kg bwt/day ), N-Zn-treated group: intraperitoneally (IP) injected with N-ZnO (5 mg/kg bwt/day), Zn-treated group: IP injected with ZnO (5 mg/kg bwt/day), Cu+N-Zn - and Cu+Zn -treated groups received the same previous doses and routes. All the experimental treatments were given 3 times / week and continued for eight weeks. Results showed that Cu- treated group caused a significant decrease in body weight and a significant increase in relative liver and kidney weights. Also, Cu caused a significant decrease in red blood cells (RBCs) count, hemoglobin (Hb) concentration, mean corpuscular hemoglobin concentration (MCHC) and platelets count with a significant increase in mean corpuscular volume (MCV) without any changes in leukocytic count. Biochemical analysis showed a significant elevation in serum liver enzymes, total and indirect bilirubin with a significant decrease in serum levels of total proteins and albumin. Also, there was a significant elevation in serum urea and creatinine levels. Cu induced a significant increase in renal and hepatic malondialdhyde (MDA) and a significant decrease in reduced glutathione (GSH). Histopathologically, Cu revealed severe degenerative and necrotic lesions in the livers and kidneys. N-Zn and Zn- treatments attenuated Cu-induced oxidative damage, alterations in the liver and kidney function tests and histopathology. Moreover, Zn treatment showed better protection against Cu-induced toxicity as compared to N-Zn.

Key words: Copper, zinc, nano-zinc, rats.

Share this Article

Applied Medical Research


BiblioMed Home
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.