Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles
 

Open Access

Original Research

RMJ. 2018; 43(4): 631-634


Biochemical markers in patients co infected with hepatitis B and C resistant to interferon therapy

Naveeda Zagham, Sadaf Jafar, Qurat-ul-Ain Zia.

Abstract
Objective: To analyze the response of male and female Hepatitis C and B infected patients to interferon therapy.
Methodology: This experimental study was conducted at Center for Research in Experimental and Applied Medicine (CREAM), Department of Biochemistry and Molecular Biology, Army Medical College, Rawalpindi, Pakistan from January 3, to April 4, 2017. Blood samples of 15 seropositive, coinfected patients of hepatitis B and C were collected. The primers specific for STAT-1 were designed based on the previously available sequences on National Centre for Biotechnology Information (NCBI), using different dry lab tools like Electronic PCR and Oligo Calc. Primers are compared with other software.
Results: All 15 coinfected patients were resistant to pegylated interferon therapy, which was administered twice weekly for six months. Fifteen subjects were healthy individuals, which were taken as controls. Among 15 coinfected patients, 13 were male and 2 females. Among healthy individuals, 7 were males and 8 were females. Their ages ranged between 27-54 years. Liver function tests (serum ALT, serum ALP, and serum bilirubin), HBV and HCV genotyping and blood complete picture were performed.
Conclusion: Most of the co-infected patients showed raised bilirubin and ALT levels. The most significant affected age group was 38-39 years. Elderly male patients were affected more with the virus as compared to females.

Key words: Hepatitis, Interferon, viruses



Share this Article


Advertisement
Journal of Molecular Pathophysiology

SUBMIT YOUR ARTICLE NOW


ScopeMed.com
BiblioMed Home
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.