Abstract

Aim: The aim of this prospective randomised blinded study was to evaluate clinical effectiveness of three different sedation protocols (intravenous propofol vs ketamine vs ketofol) in children scheduled for dental treatment.
Material and Methods: Seventy five ASA I patients, that were randomly selected in 6-12 aged children with -documented- high anxiety level were randomly divided into 3 groups: Ketamine treated group (Grup K) (a priming dose of 1 mg/kg, followed by continuous infusion dose of 50-60 µg/kg/dk), Propofol treated group (Group P) (priming dose of 2 mg/kg, followed by continuous infusion dose of 70-90 µg/kg/dk) and Ketamine plus propofol treated group (Ketofol) (Grup KP) (priming dose of 0,6 mg/kg, followed by continuous infusion dose of 40-60 µg/kg/dk). During the study period vital signs of children, the level of sedation using BIS monitor and time interval needed for full recovery were recorded in every 5 minutes. The levels of changing anxiety were measured using Children's Fear Survey Schedule – Dental Subscale (CFSS-DS) and face version of the Modified Child Dental Anxiety Scale (MCDASf).
Results: Higher complication rates were noted in Ketamine treated group (p

Key words: Intravenous Sedation, Ketofol, Ketamine, Propofol, Anxiety