Abstract

Background:
Psoriasis, also known as PsO, is a persistent skin disorder that results in erythematous, indurated, scaly, itchy, and often painful plaques. Although conventional medicine has been employed to treat psoriasis, it may cause adverse effects owing to its long-term use. Consequently, alternative medicine has become a popular option to address this issue. Coffee liberica pulp, a commonly overlooked waste product, has been found to have numerous benefits for humans.

Aim:
This study investigated the effectiveness of Liberia coffee pulp extract using an imiquimod (IMQ) -induced mouse model that replicated several features of psoriasis in humans.

Methods:
The study involved applying imiquimod (IMQ) cream and other topical treatments to the shaved dorsal skin of mice. The psoriasis Area and Severity Index (PASI) score, body weight, organ weight, expression of interleukins in the skin and serum, and full blood count were measured.

Results:
The results showed significant changes (p

Key words: Psoriasis; Liberica coffee pulp; Imiquimod; Anti-psoriatic activity; Psoriasis Area and Severity Index (PASI) score.