Understanding the pathogenicity of avian influenza viruses is poultry is an important scientific and public health challenge because of antigenic recombination and a source of novel, potentially human-pathogenic strain. Knowing the level of virulence of influenza virus is important for several reasons. The study was conducted to assess the pathogenicity and categorize the influenza virus isolate. Intravenous pathogenicity index was assay for using 6 weeks old specific pathogen free chicken for the isolate. The intravenous pathogenicity index for the isolate was 0.5. The peak of the clinical signs was at day three post infection, until a death was observed on the eight day. This study has shown that the isolate of influenza virus H5N1/2014/Ogbomoso is a low pathogenic strain.
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