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Original Article

PAFMJ. 2017; 67(5): 843-846


A COMPARISON OF PREEMPTIVE GABAPENTIN WITH PREGABALIN FOR RELIEF OF POSTOPERATIVE PAIN IN PATIENTS UNDERGOING CHOLECYSTECTOMY

Shahid Maqsood, Rao Ali Shan Khan, Abdullah Arshad.

Abstract
Objective: To compare the mean time duration of patient's first request for analgesic for pain relief after open
cholecystectomy with preoperative use of pregabalin or gabapentin.
Study Design: Randomized controlled trial.
Place and Duration of Study: Department of anesthesia, Combined Military Hospital (CMH) Peshawar during a
period of six months, from May 2014 to Nov 2014.
Material and Methods: This study included a total of 126 patients with clinical and ultrasound diagnosis of acute
cholecystitis. Patients were distributed randomly into two groups equally (63 patients in each group). Group A
was given 300mg pregabalin and group B was given 900mg gabapentin one hour before surgery by mouth.
Results: Mean age was 46.68 8.074 years for group A and 46.33 8.046 years for group B. In group A, there were
49.2% males and 50.8% females while in group B, there were 42.9% males and 57.1% females. Weight of patients
was 68.54 6.283 kg in group A and 69.75 5.778 kg in group B respectively. Mean time duration score was 37.48
7.175 minutes and 18.27 3.366 minutes in group A and B, respectively (p

Key words: Analgesia, Cholecystectomy, Gabapentin, Pregabalin.



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