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A Novel HPLC Method Validation Based on Analytical Techniques of Metoclopramide Benzamide Derivative (Metoclopramide Base) and its determination from Solid Dispersion by Solvent Evaporation Method

Nancy Kahali, Jasmina Khanam.

Abstract
The crucial endeavor in this method is focused on the study analysing recovery and column efficiency (theoretical plate) after extraction of metoclopramide from PVP K30-Metoclopramide (3:1 w/w) solid dispersion (SD). The proposed work also presents a reversed-phase high performance liquid chromatography method for the detection of very small amount of metoclopramide base followed by different analytical techniques. In this context, it may be noted that the values of LOD and LOQ for the metoclopramide base are obtained as, 0.052 g/mL and 0.159 g/mL respectively. The linearity is performed in the range of 2-20 g/mL; performance of column remained satisfactory throughout the analysis, N= 4927-2434. The percentage recovery of pure and extracted metoclopramide is ranging from 103%-105% and 86%-120% approximately. The results collectively demonstrate that the proposed method is selective. Clear isolation of metoclopramide from SD is achieved without any solid state interference.

Key words: HPLC, metoclopramide base, extraction, solid dispersion, validation


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