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Combined expression of ALEX1 and HNF-1β could improve the ability of differentiation between squamous cell carcinoma and adenocarcinoma of the uterine cervix

Hanaa A. Atwa, Mona Saeed Mohamed.

Abstract
Background; Differentiation between poorly differentiated cervical Squamous cell carcinoma (SCC)& adenocarcinoma, which is essential for proper therapy, by histopathology alone can be confusing. Immunohistochemistry can aid important data to diagnosis. The transcription factor hepatocyte-nuclear-factor-1-beta (HNF-1β) essentially participates in the visceral-endoderm differentiation from the primitive-endoderm. Arm-protein-lost-in-epithelial-cancers-on-chromosome X (ALEX) is a recent subtype of armadillo- families that had arm-repeat-domains, detected on chromosome-X.
The goal of our research; was to explore the diagnostic roles of HNF-β and ALEX-1 protein expressions in differentiation between adenocarcinoma and squamous-cell-carcinoma of the cervix using immune-histo-chemical method.
Methods; HNF-1-β and ALEX-1 protein expressions were evaluated in 32 cases of SCC and 18 cases of adenocarcinoma of the cervix. The relationships between their levels of SCC expression and the ability of panel of both markers expression in differentiation between both types of carcinomas were analyzed.
Results; we observed positive staining for HNF-1β in 83.4% (15/18) of adenocarcinoma cases. The difference of HNF-1β expression between cervical SCC and adenocarcinoma was statistically significant (p

Key words: ALEX1, uterine cervix, adenocarcinoma, HNF-1β, immunohistochemistry, squamous cell carcinoma



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