Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles

Open Access


Sudan J Paed. 2014; 14(1): 39-44

Cystic fibrosis in Sudanese children: First report of 35 cases.

Salah A Ibrahim; Munadhil A Fadl Elmola; Zain A Karrar; Ali M E Arabi; Mohamed A Abdullah; Sulafa K Ali; Fathelrahman Elawad; Tag Elsir A Ali; Mashair B Abdulrahman; Salma O Ahmed; Abelrazzag S Gundi.

Cystic fibrosis is the most common severe genetic disorder among children of European descent. It is much less common in Africans and Asians. It affects most critically the lungs causing chronic lung disease, failure to thrive and social deprivation. This is a retrospective review of 35 Sudanese patients with confirmed cystic fibrosis. About 60% of cases presented before the age of 5 years and male to female ratio was 1.7:1.0. Consanguinity was reported in 25 of the families. The main presenting features were productive cough, wheeze and clubbing. The chest X-ray showed variable degrees of hyperinflation, collapse, cystic, fibrotic changes and bronchiectasis involving both upper and lower lobes with blurring of cardiac border and hilar vasculature in the majority of cases. The sweat chloride was between 70 and 140 mmol/l in 83% of the patients (positive > 60 mmol/l). Three patients underwent DNA study and confirmed to have cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations. Gene study was not available for the rest of the patients. To our knowledge this is the first report of confirmed cases of cystic fibrosis in Sudanese patients.

Key words: Children, Africa; Cystic fibrosis; Non-Caucasians; Sudan

Similar Articles

A neuron's ambrosia: non-autonomous unfolded protein response of the endoplasmic reticulum promotes lifespan.
Homentcovschi S, Higuchi-Sanabria R
Neural regeneration research. 2022; 17(2): 309-310

The unintended consequences of the pandemic on non-pandemic research activities.
Walker J, Brewster C, Fontinha R, Haak-Saheem W, Benigni S, Lamperti F, Ribaudo D
Research policy. 2022; 51(1): 104369

The DR1‑CSE/HS system inhibits renal fibrosis by downregulating the ERK1/2 signaling pathway in diabetic mice.
Li H, Sun F, Bai S, Chang G, Wu R, Wei Y, Wen X, Xi Y, Hao J, Zaid A
International journal of molecular medicine. 2022; 49(1):

Predictors of pulmonary hypertension among children with atrial septal defects (ASD).
Chinawa JM, Chinawa AT, Ossai EN, Duru CO
The Libyan journal of medicine. 2022; 17(1): 2007603

Alternating in-source fragmentation with single-stage high-resolution mass spectrometry with high annotation confidence in non-targeted metabolomics.
Wasito H, Causon T, Hann S
Talanta. 2022; 236(): 122828

Full-text options

Latest Statistics about COVID-19
• pubstat.org

Add your Article(s) to Indexes
• citeindex.org

Covid-19 Trends and Statistics
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.

ScopeMed Web Sites