Objective: To compare the safety and efficacy of Misoprostol with Oxytocin for management of third stage of labor.
Methodology: This randomized control trial was conducted at Department of Gynecology and Obstetrics, Cantonment General Hospital, Rawalpindi, Pakistan from May to Oct 2015. A total of 212 singleton pregnant women were selected. Women were allocated to either group using simple computer generated randomization table. Group I received 10 U intramuscular Oxytocin while group II received 600ug sublingual Misoprostol. Primary outcome measures were severity of primary postpartum hemorrhage, amount of blood loss and side effects of drugs.
Results: The mean blood loss was 303.50+225.35 in group I and 271.30+206.205 in group II (p=0.035). The average drop in hemoglobin was 0.84+0.78 in group I and 0.81+0.79 in group II (p=0.980). There is no association in two groups with regard to PPH, repeat dose, complications and blood transfusion (p=0.86).
Conclusion: Misoprostol was better than Oxytocin regarding average blood loss for the management of third stage of labor.
Key words: Misoprostol, Oxytocin, Prevention, Postpartum hemorrhage.