Home|Journals|Articles by Year Follow on Twitter| Subscribe to List

Directory for Medical Articles
 

Open Access

Original Article



Serum paraoxonase-1 activity in Egyptian premenopausal women with metabolic syndrome and its relation with recurrent pre-eclampsia risk

Walaa Basha, Walaa Yousef, Ahmed Ismail, Eman Younes, Tamer Hussein, Osama Azmy.

Abstract
Background: Association of paraoxonase-1 (PON-1) with the metabolic syndrome (MS) and recurrent preeclampsia has not been previously investigated among Egyptian premenopausal women. Pre-eclampsia is a multisystem disorder and its etiopathogenesis has not yet been fully understood.
Aim: The aim of the study is to investigate serum PON-1 activity in Egyptian women with MS and assess its potential link with the incidence of recurrent pre-eclampsia.
Method: The study group consisted of 60 premenopausal women with MS and 60 healthy controls. In the MS group, 26 patients had past history of recurrent pre-eclampsia. The enzymatic activity of serum PON-1 was measured by spectrophotometer. Serum lipids were measured by enzymatic colorimetric methods using a Hitachi auto-analyzer.
Results: MS cases with and without recurrent pre-eclampsia showed significantly reduced PON-1 activity compared to healthy controls. Significant negative correlations were observed between PON-1 levels and BMI, SBP, DBP, serum total cholesterol, TG and LDL-C and positive correlation with HDL–C in MS cases either with or without recurrent pre-eclampsia. In addition, MS cases with history of recurrent pre-eclampsia showed significantly lower levels of PON-1 than those without.
Conclusions: Serum PON-1 is significantly reduced in women with MS and might alter their lipid profile. Low PON-1 levels could contribute to the great risk of recurrent preeclampsia in MS women.

Key words: Serum PON-1, metabolic syndrome, recurrent preeclampsia, serum lipids, women


Full-text options

Full-text Article


Share this Article


Readers of this article also read the following articles
»Theory of mind, aggression and impulsivity in patients with synthetic cannabinoid use disorders: a case-control study
»Neuropathic pain
»Promotive effects of 5-Aminolevulinic acid on growth, photosynthetic gas exchange, chlorophyll, and antioxidative enzymes under salinity stress in Prunnus persica (L.) Batseh Seedling
»Admission Rate of Patients with Most Common Psychiatric Disorders in Relation to Seasons and Climatic Factors During 2010/2011
»Idiopathic hyperhidrosis: Is response to parasympathetic function test altered?
»ACADEMIC STRESS: A CONCEPTUAL UNDERSTANDING BASED ON AYURVEDIC PRINCIPLES
»Seasonal Influence on Meat Quality of Small and Medium Scale Broiler Farming in Bangladesh
»In -vitro analysis of antiallergic activity of Ocimum sanctum (Tulsi/Holy Basil) and Calotropis gigantean (AaK) for reduction of wheat allergenic proteins
»An analysis of cases presented to pediatric emergency department with acute abdominal pain
»Resource use Efficiency in Sweet Potato Production in Odeda Local Government Area, Ogun State, Nigeria
»Quantitative and Qualitative Evaluation of The Structural Designing of Medical Informatics Dynamic Encyclopedia



Advertisement
American Journal of Preventive Medicine and Public Health

SUBMIT YOUR ARTICLE NOW




ScopeMed.com
BiblioMed Home
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.