Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles

Open Access

Original Article

Serum paraoxonase-1 activity in Egyptian premenopausal women with metabolic syndrome and its relation with recurrent pre-eclampsia risk

Walaa Basha, Walaa Yousef, Ahmed Ismail, Eman Younes, Tamer Hussein, Osama Azmy.

Background: Association of paraoxonase-1 (PON-1) with the metabolic syndrome (MS) and recurrent preeclampsia has not been previously investigated among Egyptian premenopausal women. Pre-eclampsia is a multisystem disorder and its etiopathogenesis has not yet been fully understood.
Aim: The aim of the study is to investigate serum PON-1 activity in Egyptian women with MS and assess its potential link with the incidence of recurrent pre-eclampsia.
Method: The study group consisted of 60 premenopausal women with MS and 60 healthy controls. In the MS group, 26 patients had past history of recurrent pre-eclampsia. The enzymatic activity of serum PON-1 was measured by spectrophotometer. Serum lipids were measured by enzymatic colorimetric methods using a Hitachi auto-analyzer.
Results: MS cases with and without recurrent pre-eclampsia showed significantly reduced PON-1 activity compared to healthy controls. Significant negative correlations were observed between PON-1 levels and BMI, SBP, DBP, serum total cholesterol, TG and LDL-C and positive correlation with HDL–C in MS cases either with or without recurrent pre-eclampsia. In addition, MS cases with history of recurrent pre-eclampsia showed significantly lower levels of PON-1 than those without.
Conclusions: Serum PON-1 is significantly reduced in women with MS and might alter their lipid profile. Low PON-1 levels could contribute to the great risk of recurrent preeclampsia in MS women.

Key words: Serum PON-1, metabolic syndrome, recurrent preeclampsia, serum lipids, women

Similar Articles

Safe Zones for Percutaneous Carpal Tunnel Release.
Wu PT, Chern TC, Wu TT, Shao CJ, Wu KC, Kuo LC, Jou IM
Hand clinics. 2022; 38(1): 83-90

Contributing factors common to COVID‑19 and gastrointestinal cancer.
Kostoff RN, Briggs MB, Kanduc D, Shores DR, Kovatsi L, Drakoulis N, Porter AL, Tsatsakis A, Spandidos DA
Oncology reports. 2022; 47(1):

Cost-Effectiveness of Sonography-Guided Surgery.
Kinanga R, Moungondo F
Hand clinics. 2022; 38(1): 65-73

Preoperative Evaluation of Thenar Muscles in Carpal Tunnel Syndrome by Ultrasonography.
Nagura I, Kanatani T, Harada Y, Takase F, Inui A, Mifune Y, Kuroda R
Hand clinics. 2022; 38(1): 55-58

De Novo Molecular Design with Chemical Language Models.
Grisoni F, Schneider G
Methods in molecular biology (Clifton, N.J.). 2022; 2390(): 207-232

Full-text options

Latest Statistics about COVID-19
• pubstat.org

Add your Article(s) to Indexes
• citeindex.org

Covid-19 Trends and Statistics
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.

ScopeMed Web Sites