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J App Pharm Sci. 2018; 8(1): 159-164

Effect of bee venom phonophoresis in obese polycystic ovarian women: A Single Blind Randomized Controlled Trial

Maram M. Yasin, Eman A. Elhosary, Hamada Ahmed Hamada, Amel M. Yousef, Mohamed Shahin, Dalia Mosaad.

Polycystic ovary syndrome (PCOS) is a complex disorder that adversely affect fertility. The purpose of this study was to determine the effect of bee venom (BV) phonophoresis in the treatment of obese PCOS women. Forty-six obese PCOS women with age range, 18- 39 years and body mass index 29- 43 kg/m2 were recruited. Participants were assigned randomly into two equal groups; group A, 23 PCOS patients received phonophoresis with BV topical application in addition to low caloric diet (1200-1400 kcal /day) and group B (control group), 23 PCOS patients followed low caloric diet (1200-1400 kcal /day) and sham ultrasound sessions with plain gel without BV. Assessment was done by biochemical analysis of luteinizing hormone (LH), follicle stimulating hormone (FSH), LH/FSH ratio, and progesterone (P4) levels, measured before, after 7 weeks, and after 14 weeks of treatment. Forty-six obese PCOS women (group A n=23; group B n=23) were randomized and analyzed. Comparison between groups revealed that there was no significance difference between both groups after 7 weeks and after 14 weeks of treatment except for P4 that showed a significant increase in group A after 7 weeks of treatment and marked decrease in LH and LH/FSH ratio in the middle of treatment at group A. BV phonophoresis with diet and physical activity have beneficial effect in the treatment of obese PCOS women.

Key words: Polycystic ovary syndrome, Phonophoresis, Bee venom.

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