Polycystic ovary syndrome (PCOS) is a complex disorder that adversely affect fertility. The purpose of this study was to determine the effect of bee venom (BV) phonophoresis in the treatment of obese PCOS women. Forty-six obese PCOS women with age range, 18- 39 years and body mass index 29- 43 kg/m2 were recruited. Participants were assigned randomly into two equal groups; group A, 23 PCOS patients received phonophoresis with BV topical application in addition to low caloric diet (1200-1400 kcal /day) and group B (control group), 23 PCOS patients followed low caloric diet (1200-1400 kcal /day) and sham ultrasound sessions with plain gel without BV. Assessment was done by biochemical analysis of luteinizing hormone (LH), follicle stimulating hormone (FSH), LH/FSH ratio, and progesterone (P4) levels, measured before, after 7 weeks, and after 14 weeks of treatment. Forty-six obese PCOS women (group A n=23; group B n=23) were randomized and analyzed. Comparison between groups revealed that there was no significance difference between both groups after 7 weeks and after 14 weeks of treatment except for P4 that showed a significant increase in group A after 7 weeks of treatment and marked decrease in LH and LH/FSH ratio in the middle of treatment at group A. BV phonophoresis with diet and physical activity have beneficial effect in the treatment of obese PCOS women.
Polycystic ovary syndrome, Phonophoresis, Bee venom.