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Histological and Oxidative Alterations in the Kidney of Rats Induced with Hypothyroidism and Amelioration with Withania Somnifera and Shilajit

Ramya Boinepally, Anand Kumar Aryasomayajula, Gopala Reddy Aalla, Shiva Kumar Pabbathi.


The experiment was conducted to evaluate blood glucose, antioxidant parameters and histopathological changes in kidney of experimentally induced hypothyroidism in rats. The study was for a period of 3 months in 21 days old weaned female Sprague drawly rats (96). The rats were divided into 8 groups with 12 no.s in each group. They were treated as: Group 1: Eut-hyroid Group 2: Hypothyroidism with Methimazole @ 0.02% Group 3: Hypothyroid + LT4 Group 4: Withania somnifera root extract control Group 5: Hypothyroid +Withania somnifera root extract Group 6: Shilajit control Group 7: Hypothyroid + Shilajit Group 8: Hypothyroid +Withania somnifera root extract + Shilajit, both herbs @ 100 mg/Kg b. wt. The serum T3, T4 concentrations and glutathione in hypothyroid group were significantly (p

Key words: Hypothyroidism, Methimazole, Shilajit, Withania somnifera

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