The experiment was conducted to evaluate blood glucose, antioxidant parameters and histopathological changes in kidney of experimentally induced hypothyroidism in rats. The study was for a period of 3 months in 21 days old weaned female Sprague drawly rats (96). The rats were divided into 8 groups with 12 no.s in each group. They were treated as: Group 1: Eut-hyroid Group 2: Hypothyroidism with Methimazole @ 0.02% Group 3: Hypothyroid + LT4 Group 4: Withania somnifera root extract control Group 5: Hypothyroid +Withania somnifera root extract Group 6: Shilajit control Group 7: Hypothyroid + Shilajit Group 8: Hypothyroid +Withania somnifera root extract + Shilajit, both herbs @ 100 mg/Kg b. wt. The serum T3, T4 concentrations and glutathione in hypothyroid group were significantly (p
Key words: Hypothyroidism, Methimazole, Shilajit, Withania somnifera
|
