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The Effect of Darapladib Therapy for the Expression of Lp-PLA2 in Dyslipidemia and Type 2 Diabetes Mellitus Atherosclerosis Model

Titin Andri Wihastuti, Rosaria Dian Lestari, Teuku Heriansyah.


Abstract

Lipoprotein associated phospholipase A2 (Lp-PLA2) activity is suspected to contribute in atherosclerosis development. This study investigated the role of Lp-PLA2 and Lp-PLA2 selective inhibitor (darapladib) in atherogenesis. Conclucively, Darapladib significantly decreased Lp-PLA2 protein but was shown to increase the Lp-PLA2 mRNA levels in blood and aortic tissue in dyslipidemia and type 2 DM model.

Key words: darapladib, dyslipidemia, atherosclerosis, T2DM, Lp-PLA2, LP-PLA2 inhibitor






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