Home|Journals|Articles by Year

Directory for Medical Articles
 

Review Article

J App Pharm Sci. 2017; 7(11): 184-202


Biological Activities of Organometalloid (As, At, B, Ge, Si, Se, Te) Steroids

Valery M. Dembitsky, Tatyana A. Gloriozova, Vladimir V. Poroikov.


Abstract

Organometalloid steroids (OS) represent an interesting class of biologically active hormones including anabolic steroids. Currently, more than 1,000 OS have been synthesized, and many are widely used in medical practice, including sports medicine and pharmacology. In this review, we present structures of OS that contain (along with the composition of a molecule of metalloids) As, At, B, Ge, Si, Se, and Te. We also used an algorithm that works with a PASS programme containing approximately one million chemical structures and approximately 8,000 validated biological activities and allows you to calculate the predicted activity from the chemical structure of the steroidal molecule. From the huge variety of steroidal structures, we selected more than 100 OS that belong to seven groups, including boronic steroids, arsenosteroids, astatosteroids, germylated steroids, silasteroids, selena steroids and tellura steroids. The biological activity for these groups of OS is presented in this paper. Additionally, it is important to note that these selena and tellura steroids showed a high anticancer activity and they can be used as anti-parkinsonian, anti-Alzheimer's disease and anti-neurodegenerative agents.

Key words: Organometalloids, boronic steroids, arsenosteroids, astatosteroids, germylated steroids, silasteroids, selena steroids, tellura steroids, activities






Full-text options


Share this Article



Online Article Submission
• ejmanager.com
• ojshosting.net







Do you want to use OJS for your journal ?
work with an experienced partner
www.OJSHosting.net

eJManager.com
Review(er)s Central
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.