Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles
 

Open Access

Original Article



Cisplatin-Induced Nephrotoxicity in Rats: Modulatory Role of Simvastatin and Rosuvastatin against Apoptosis and Inflammation.

Rasha E. Mostafa, Dalia O. Saleh, Dina F. Mansour.

Abstract
Cisplatin use as a chemotherapeutic agent is restricted due to its nephrotoxicity. The current study investigates the possible mechanisms responsible for the nephro-protective effects of simvastatin (SIM) and rosuvastatin (RST) in cisplatin-induced nephrotoxicity in rats. Acute nephrotoxicity was induced in rats by single injection of cisplatin on the 10th day of the treatment period. Two groups received SIM and RST daily respectively, for 10 days prior to cisplatin injection. 5 days post cisplatin injection, blood samples were taken, rats were scarified and renal tissues were isolated for biochemical, immunohistochemical and histopathological assessments. Results of the study revealed that cisplatin-injected rats showed a reduction in the relative kidney weight with an elevation in the serum kidney function and renal inflammatory mediators viz. myeloperoxidase (MPO), tumor necrosis factor-alpha (TNF-α), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) and interlukin-1β (IL-1β). Kidneys isolated from rats injected with cisplatin showed overexpression of apoptotic markers and a decrease in the expression of the anti-apototic markers. SIM and RST significantly improved relative kidney weight, serum kidney function and restored renal tissue concentrations of inflammatory mediators. Decreased renal expression of caspases-3, Bax with increased Bcl-2 expression and improved histopathological pictures of treatment groups were observed. Our results suggest that SIM and RST have nephroprotective properties against cisplatin-induced nephrotoxicity due to their anti-inflammatory and anti-apoptotic effects.

Key words: Cisplatin; simvastatin; rosuvastatin, nephrotoxicity; Bax; Bcl-2; TNF-α, IL-1β; MPO; NF- kB; Caspase-3; Rats.



Similar Articles

A flexible electrode array for determining regions of motor function activated by epidural spinal cord stimulation in rats with spinal cord injury.
Mao GW, Zhang JJ, Su H, Zhou ZJ, Zhu LS, Lü XY, Wang ZG
Neural regeneration research. 2022; 17(3): 601-607

Biomimetic chitosan scaffolds with long-term controlled release of nerve growth factor repairs 20-mm-long sciatic nerve defects in rats.
Liu FD, Duan HM, Hao F, Zhao W, Gao YD, Hao P, Yang ZY, Li XG
Neural regeneration research. 2022; 17(5): 1146-1155

Clinical Significance of Elevated Serum Caspase-1 Levels in Patients With Ankylosing Spondylitis.
Kim SH, Lee JH, Jeong HJ, Kim JM, Baek WK, Kim TH, Jun JB, Son CN
Annals of laboratory medicine. 2022; 42(2): 293-295

Exosomes derived from bone marrow mesenchymal stem cells protect the injured spinal cord by inhibiting pericyte pyroptosis.
Zhou Y, Wen LL, Li YF, Wu KM, Duan RR, Yao YB, Jing LJ, Gong Z, Teng JF, Jia YJ
Neural regeneration research. 2022; 17(1): 194-202

Neat1 decreases neuronal apoptosis after oxygen and glucose deprivation.
Chai WN, Wu YF, Wu ZM, Xie YF, Shi QH, Dan W, Zhan Y, Zhong JJ, Tang W, Sun XC, Jiang L
Neural regeneration research. 2022; 17(1): 163-169


Full-text options


Latest Statistics about COVID-19
• pubstat.org


Add your Article(s) to Indexes
• citeindex.org






Covid-19 Trends and Statistics
ScopeMed.com
CiteIndex.org
CancerLine
FoodsLine
PhytoMedline
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.



ScopeMed Web Sites