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Original Article

J App Pharm Sci. 2018; 8(2): 106-111


Sildenafil, a phosphodiesterase-5-inhibitor decreased the oxidative stress induced by carbon tetrachloride in the kidney of rats: A preliminary study

Anne A Adeyanju, Olorunfemi R Molehin, Ezekiel T Ige, Lanre O Adeleye, Oluwakemi V Omoniyi.




Abstract

Carbon tetrachloride (CCl4) is a well-established nephrotoxin. Free radical generation has been described as one of the mechanisms of inducing its nephrotoxicity. This preliminary study investigated the protective effect of sildenafil (SILD) in CCl4-induced oxidative stress in rat kidney. Thirty male albino wistar rats weighing between 150–200g were randomly divided into five groups, each consisting of 6 rats. Control group received physiological saline (10ml/kg, p.o.), another group received 0.5ml/kg/i.p. of CCl4 while three separate groups were pretreated with SILD at 5mg, 10mg and 20mg/kg respectively before CCl4 challenge. Animals were sacrificed 24 hours after CCl4 administration. Renal biomarkers were measured in the serum. In addition, antioxidant assays and histopathological studies were carried out. CCl4 treatment produced no significant change in the serum levels of creatinine and BUN (P>0.05). However, CCl4 significantly (p

Key words: Nephrotoxicity; adriamycin; oxidative stress; rat; sildenafil






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