Abstract

Objective: This study aimed to assess the public awareness, motivation, and concerns regarding genetic knowledge and genetic testing among Saudi citizens in Madina city.
Methods: A cross-sectional questionnaire survey was conducted between February and October 2025. The survey assessed demographic characteristics, basic genetic knowledge, motivation regarding genetic testing for medical and research purposes, willingness to disclose results, and perception of stigma.
Results: The findings revealed limited awareness and understanding of basic concepts in the “others” marital status group (divorced or widowed). A significant association was found between being a single male participant and not disclosing genetic test results. Although most participants believed that individuals with genetic diseases are not stigmatized, a minority acknowledged the presence of stigma. Some participants stated they
would decline a genetic test for medical reasons due to fear of the results and uncertainty about certain genetic information. A substantial group expressed hesitation regarding genetic testing for research purposes due to privacy and trust issues.
Conclusion: This study highlighted gaps in genetic awareness, concerns regarding disclosure, and trust issues in research-related genetic testing. Addressing these issues requires targeted community education, accessible genetic counselling, and clearer communication about the purpose and benefits of genetic testing. Strengthening transparency and data governance policies is essential to enhance public trust and support responsible participation in genetic research.

Key words: Genetic, genetic testing, knowledge, motivations, research purposes, Saudi Arabia.