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Dynamics of airway functions in untreated hypothyroidism

Geetanjali Purohit, Trushna Shah, Jaman Mohan Harsoda.


Background: Hypothyroidism is a hormonal disorder, more prevalent in females, affects respiratory systems at early stage.

Objectives: Present study was carried out to observe the expiratory and inspiratory dynamics of airway functions in recently diagnosed hypothyroid females without medication and its comparison with hypothyroid females with hormonal therapy and euthyroid females. Parameters studied were forced vital capacity (FVC), forced expiratory volume (FEV1), FEV1%, forced inspiratory vital capacity (FIVC), FIV1, FIV1%, forced expiratory flow (FEF25-75%), FEF0.2-1.2%, FEF25%, FEF50%, FEF75%, peak expiratory flow (PEF), and peak inspiratory flow.

Materials and Methods: Twenty-one (n = 21) recently diagnosed hypothyroid women without medication (Group-1) and 19 hypothyroid women taking medication for the last 6-8 months (Group-2) were studied. Hypothyroidism was diagnosed on the basis of serum thyroid-stimulating hormone level (

Key words: Forced Vital Capacity; Forced Expiratory Volume 1; Peak Expiratory Flow; Thyroid-stimulating Hormone; Hypothyroid; Euthyroid

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