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Original Article

J App Pharm Sci. 2020; 10(6): 116-122

Study of a tooth gel formulation for hygiene and oral sequelae management in irradiated patients

Ana Carolina Lara Ribeiro, Marina Goulart da Silva, Harley da Silva Tavares, Ana Gabriela Reis Solano, Ana Julia Pereira Santinho Gomes.

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Cervical-facial radiotherapy causes innumerable sequelae, being systemic or restricted to the oral environment. The oral mucosa of these patients is profoundly compromised by radiotherapeutic treatment with or without chemotherapy, presenting several complications. Dentifrices containing sodium lauryl sulfate cause damage, as they lead to dryness of the mucosa. The objective of this work was to develop a dentifrice capable of minimizing xerostomia related to a lower abrasive effect, which was intended for hygiene, prevention of caries, control of dental biofilm, and tooth sensitivity in cancer patients. The qualitative composition and physicochemical characteristics of ten dentifrices were analyzed, which enabled the preparation of the proposed formulation (PF) that was analyzed periodically for 180 days. The quantitative analysis of spreadability not only indicated favorable behavior of the PF in relation to the packaging and storage conditions but also revealed the need to raise the propylene glycol concentration in the PF to avoid the occurrence of syneresis after 60 days. Furthermore, pH data showed that the PF is compatible with the pH of oral homeostasis thus avoiding the occurrence of dental demineralization. It is suggested that the PF has a singular composition and physicochemical quality to be used as a suitable dentifrice for patients undergoing anticancer therapy.

Key words: Formulation development; Dentifrice; Physicochemical properties; Cancer patient

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