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Acute hepatitis with non-alcoholic fatty liver disease-expanding clinical spectrum in COVID-19 exposed children: case report and review of literature

Sandeep Jhajra, Akshada Sharma, Kumar Diwakar, Bhupendra Kumar Gupta, Sanjay Kumar Tanti.


Coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) can adversely affect extra-pulmonary organs, such as the liver, heart and gastrointestinal tract apart from lungs. Although studies are showing that serum glutamic-oxaloacetic transaminase and serum glutamic-pyruvic transaminase are mildly elevated along with serum bilirubin in adult patients with mild to severe cases of COVID-19 disease, data are limited regarding liver injury in children infected with COVID virus. We report the case of a 9-year-old female patient who developed signs and symptoms of upper respiratory tract infection due to COVID-19 virus infection and subsequently developed fatty liver disease on follow-up. To our knowledge, this is the second case report in children showing an association between non-alcoholic fatty liver disease and SARS-CoV-2 virus infection.

Key words: Coronavirus; Liver injury; Non-alcoholic fatty liver disease.

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