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Comparative study of anti-nociceptive effect of venlafaxine with tramadol by tail-flick test in animal model of mice

Sandeep Bandapati, Karuna Sree Podila, Venkata Rao Yadala.



Abstract
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Background: Pain management is ever challenging task to the treating physicians. Always there is search for new medication for pain management. In this context, use of antidepressants in pain management had shown promising results. Venlafaxine is a newer antidepressant drug belonging to selective norepinephrine reuptake inhibitor class, this study was planned to evaluate the venlafaxine antinociceptive effect.

Aims and Objectives: This study aims to evaluate the venlafaxine antinociceptive activity and to compare the venlafaxine antinociceptive effect with tramadol by tail-flick test in an animal model in albino mice.

Materials and Methods: Albino mice of either sex were randomly selected with reaction time of

Key words: Venlafaxine; Tail-Flick Test; Analgesic; Chronic Pain

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