Abstract

In recent years, autologous concentrated blood products have become increasingly widespread in dentistry and various medical disciplines as biologically active agents for wound healing and tissue regeneration. These autologous blood concentrates have emerged as effective biological adjuncts by accelerating wound healing and contributing to the reduction of postoperative pain and complications. Clinical studies indicate that platelet-rich fibrin (PRF) and its derivatives, in particular, provide favorable outcomes in both hard and soft tissue regeneration and are expected to be increasingly incorporated into minimally invasive treatment strategies. The aim of this review is to comparatively evaluate the biological basis, preparation methods, and clinical effects of autologous blood products in light of the current literature. In this review, experimental studies, systematic reviews, and randomized controlled trials involving human or animal models published between 2010 and 2025 were identified through searches of PubMed, Scopus, Web of Science, and Google Scholar using relevant keywords. Studies of low methodological quality, those with incomplete data, or publications available only in abstract form were excluded. This study was designed as a narrative review and did not follow PRISMA guidelines. A total of 120 articles were screened during the search process, of which 44 studies meeting the inclusion criteria were included in the final analysis. Current studies and systematic reviews indicate that autologous concentrated blood products function as effective biological agents in regenerative medicine and dentistry, contributing to improved clinical outcomes and enhanced patient satisfaction.

Key words: Platelet-rich fibrin, platelet-rich plasma, tissue regeneration, autologous blood products