A twelve year old local castrated male dog presented with complaint of difficult urination and bloody urine was diagnosed as having metastatic transmissible venereal tumour based on the results of cytology and per-cutaneous abdominal ultrasound. Physical examination revealed enlarged inguinal lymph nodes and distended but firm prepuce. In addition, the preputial orifice had a friable cauliflower growth. Results of complete blood count revealed normal packed cell volume and severe neutrophilic leukocytosis. Cytology of impression smear from the preputial mass and fine needle aspirates of inguinal lymph nodes revealed round cells with large nucleus/cytoplasmic ratio, prominent chromatin clumping and numerous cytoplasmic vacuolation. Treatment involved weekly intravenous injection of vincristine sulphate (0.5mg/m2) for six weeks, resulting in progressive reduction in prepuce and inguinal lymph nodes and complete resolution of the preputial mass by week three. In conclusion, diagnosis of transmissible venereal tumor with metastasis to inguinal lymph node in a dog twelve years after castration suggests that surgical castration is not sufficient to protect dogs from coitally transmitted infection.
Key words: Cytology, Vincristine, Tumor, Castrated, Preputial mass
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