DNA Tattooing Pain Or Gain?Kumaragurubaran Karthik, Narayanan Selvaraj Muneeswaran, Manickam Kesavan, Paramasivam Tamilmahan, Santhosh Shinde.
Tattooing is one of a number of DNA delivery methods which results in an efficient expression of an introduced gene in the epidermal and dermal layers of the skin. The tattoo procedure causes minor mechanical injuries followed by hemorrhage, necrosis, inflammation and regeneration of the skin and thus non-specifically stimulates the immune system. DNA vaccines delivered by tattooing have been shown to induce higher specific humoral and cellular immune responses than intramuscularly injected DNA.
Key words: DNA tattooing, DNA vaccine, plasmid DNA, ex vivo skin