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J App Pharm Sci. 2018; 8(2): 164-167

In vitro Anthelmintic Activity of Acanthus ilicifolius Leaves Extracts on Ascardia galli and Pherethima postuma

Dadang Irfan Husori, Sumardi Sumardi, Heron Tarigan, Selviani Gemasih, Sri Rahayu Ningsih.


Parasitic worms in the chicken gastrointestinal tract are a chronic problem that becomes one of the causes of economic losses in the poultry. The aim of the study was to evaluate the anthelmintic activity of Acanthus ilicifolius leaves extract against Ascaridia galli and Pherethima posthuma. In vitro anthelmintic activity test was performed using 3 concentrations (15, 20, and 25 mg/ml) of ethanol, aqueous, and n-hexane extract of Acanthus ilicifolius leaves against Ascaridia galli and Pherethima posthuma. Pyrantel pamoate used as positive control, while the negative control using normal saline and distilled water. The vehicle control using carboxymethyl cellulose. The time to paralyze and time to death of worms were observed as anthelmintic activity parameter. The study also conducted phytochemical screening of the extract. The ethanol, aqueous and n-hexane of Acanthus ilicifolius leaves extracts of 15, 20, and 25 mg/ml concentration showed anthelmintic activity in Ascaridia galli and Pherethima posthuma. Anthelmintic activity was dose-dependent manner. Meanwhile, the results of phytochemical screening showed the three types of extracts contained secondary metabolites such as alkaloids, flavonoids, tannins, saponins and steroids. The ethanol, aqueous and n-hexane extracts of Acanthus ilicifolius leaves possessed anthelmintic activity against worms Ascaridia galli and Pherethima posthuma.

Key words: anthelmintic, Acanthus ilicifolius, Ascaridia galli, Pherethima postuma, pyrantel pamoate

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