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A Randomized Study of Biomimetic Peptides Efficacy and Impact on the Growth Factors Expression in the Hair Follicles of Patients with Telogen Effluvium

Alexey Alekseevich Kubanov, Yulia Albertovna Gallyamova, Olga Andreevna Korableva.


The article studies the effect of biomimetic peptides on the growth factors expression in the hair follicle and to evaluate the therapeutic efficacy in women with telogenic hair loss. The method of immunofluorescence study of scalp specimens taken by the punch biopsy (4mm) from the frontotemporal areas before and after the therapy was used. 30 female patients with telogen effluvium aged between 20 and 56 years were recruited for the research and randomly divided into two groups. Patients of group I were treated with lotion based on biomimetic peptides, and those of group II were treated with 0.9% saline. The therapeutic efficacy of biomimetic peptides in women with telogenic hair loss was assessed by trichoscopy and phototrichography.
A change in the expression of VEGF, KGF, TGF-β1growth factors was found in women with telogenic hair loss as opposed to the healthy ones. The therapeutic efficacy of the use of biomimetic peptides to treat women with telogenic hair loss was evaluated. After the therapy, a significant increase in the VEGF, EGF expression and a decrease in KGF and TGF-β1 expression were noted.

Key words: hair loss, telogen effluvium, hair follicle, hair cycle, hair growth, growth factors, peptides.

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