Home|Journals|Articles by Year|Audio Abstracts
 

Short Communication

J App Pharm Sci. 2017; 7(9): 219-223


Antiviral and antiparasitic activities of clovamide: the major constituent of Dichrostachys cinerea (L.) Wight et Arn

Reham T. El-Sharawy, Ahmed Elkhateeb, Mona M. Marzouk, Rasha R. Abd El-Latif, Salah Eldeen Abdelrazig, Mohamed A. El-Ansari.




Abstract

ABSTRACT
The application of different chromatographic and spectroscopic techniques to the aqueous alcoholic leaves extract of Dichrostachys cinerea (L.) Wight et Arn. (Mimosaceae) led to the isolation and identification of ten phenolic compounds. Clovamide, apigenin-7-O-apiosyl (1→2) glucoside and chrysoeriol-7-O-apiosyl (1→2) glucoside were isolated for the first time from the plant, in addition to previously reported four flavonol glycosides (quercetin-3-O-rhamnopyranoside, quercetin-3-O-glucopyranoside, myricetin-3-O-rhamnopyranoside and myricetin-3-O-glucopyranoside), and three aglycones (myricetin, apigenin and kaempferol). Clovamide as a major constituent was investigated for its antiviral and antitrypanosomal activities. It showed a significant antiviral effect against H5N1 influenza A virus with % inhibition (74%) and a momentous trypanocidal effect against Trypanosoma evansi with IC50 value of 3.27 μg/ml, compared with the standard drug; diminazene aceturate (IC50=0.72μg/ml).

Key words: Keywords: Dichrostachys cinerea, clovamide, phenolics, antitrypanosomal, anti-H5N1






Full-text options


Share this Article


Online Article Submission
• ejmanager.com




ejPort - eJManager.com
Refer & Earn
JournalList
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under Creative Commons Attribution 4.0 International License (CC BY), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.