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Case Report

Clonazepam-induced acute liver injury: A case report

Malini Muraleedharan Nair, Dhanya Susan Abraham, Neethu C M.


Clonazepam belongs to the benzodiazepine class of drugs (benzodiazepine derivative). It is used both as an anticonvulsant and in the treatment of panic disorder with or without agoraphobia. The most frequent adverse drug reactions of clonazepam are sedation or drowsiness, ataxia or hypotonia, and behavioral disturbances. Hepatomegaly and transient elevations in serum aminotransferases and alkaline phosphatase concentrations may occur in patients receiving this drug, but the frequency of the reaction has not been well defined. Here, we report that an acute psychosis case was the patientÂ’s laboratory reports showed a transient elevation in serum transaminases and alkaline phosphatase levels after clonazepam was administered.

Key words: Clonazepam; Benzodiazepines; Serum Transaminases; Alkaline Phosphatase; Adverse Drug Reaction

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