Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles
 

Open Access

Original Research



A study on the effect of atorvastatin on the pharmacokinetic and antidepressant activity of fluoxetine

Bimbishar Bhattarai, Shivakumar Swamy, Sanjay Raj Baral, Chandra Prakash Acharya.

Abstract
Background: Polypharmacy is of wide concern in drug interaction. It is the leading cause of adverse drug reaction, and consequently, increasing the possibility of hospitalization and escalating the cost of care. The incidence of coexisting depression and hyperlipidemia in patients is generally managed by providing numerous drugs for a longer period of time.

Aims and Objectives: This study was conducted to observe the effect of atorvastatin on pharmacokinetic parameters of fluoxetine in healthy albino rabbits and to find possible interactions of atorvastatin on the antidepressant activity of fluoxetine using animal screening test.

Materials and Methods: Two drugs: Fluoxetine and atorvastatin used concurrently were selected. Healthy male albino rabbits were used to determine the effect of atorvastatin on fluoxetine addressing its pharmacokinetic parameters, whereas rats and mice were used to assess the antidepressant activity of fluoxetine. Two animal models were used to determine its antidepressant activity. Forced swim test (FST) and tail suspension test (TST) were employed in exploring antidepressant activity. High-performance liquid chromatography was used to estimate fluoxetine concentration.

Results: The concentration of serum fluoxetine showed slight increment after the atorvastatin treatment for 7 days at 2nd, 4th, 8th, 16th, and 24th h. The pharmacokinetic parameters: Area under the curve, area under first-order moment curve, t1/2, and Cmax of fluoxetine varied after atorvastatin treatment for 1 week in healthy albino rabbits. ‘’Furthermore, atorvastatin treatment for a week revealed a reduction in immobility time in rats and mice as shown by the FST and TST respectively.

Conclusion: The results revealed the possibility of drug-drug interaction between fluoxetine and atorvastatin.

Key words: Depression; Fluoxetine; Atorvastatin; Drug-drug Interaction; Forced Swim Test, Tail Suspension Test



Similar Articles

Optogenetic activation of intracellular signaling based on light-inducible protein-protein homo-interactions.
Huang P, Zhao Z, Duan L
Neural regeneration research. 2022; 17(1): 25-30

Transcranial magnetic stimulation in animal models of neurodegeneration.
Uzair M, Abualait T, Arshad M, Yoo WK, Mir A, Bunyan RF, Bashir S
Neural regeneration research. 2022; 17(2): 251-265

Clinical Evaluation of the Rapid STANDARD Q COVID-19 Ag Test for the Screening of Severe Acute Respiratory Syndrome Coronavirus 2.
Kim HW, Park M, Lee JH
Annals of laboratory medicine. 2022; 42(1): 100-104

Three Methods for Peptide Cyclization Via Lactamization.
Posada L, Serra G
Methods in molecular biology (Clifton, N.J.). 2022; 2371(): 3-17

Stroke recovery enhancing therapies: lessons from recent clinical trials.
Rogalewski A, Schäbitz WR
Neural regeneration research. 2022; 17(4): 717-720


Full-text options


Latest Statistics about COVID-19
• pubstat.org


Add your Article(s) to Indexes
• citeindex.org






Covid-19 Trends and Statistics
ScopeMed.com
CiteIndex.org
CancerLine
FoodsLine
PhytoMedline
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright © ScopeMed® Information Services.



ScopeMed Web Sites