Objective: Behcet's Disease is a chronic multisystemic inflammatory vasculitis and presents with relapsing-remitting oral and genital ulcers accompanied by iridocyclitis. Although Behcet's Disease affects people worldwide, it is most common in Mediterranean, Middle East and Far East.
Material and Methods: This study was performed at a university hospital department of obstetrics and gynecology, division of perinatology. The archives of perinatology department were searched for 33 patients with a prenatal diagnosis of Behcet's Disease in the period 2012-2017.
Results: We observed that 27.2% of patients were not under treatment however 72.8% of patients were taking colchicine, azathioprine, prednisolone, interferon-alpha, adalimumab and combination of these drugs. Only 8 of the 33 patients (24.2%) had relapse during follow-up period. Mean gestational age at time of delivery was 38.5 ±2.6 weeks' gestation and the mean birth weight was 3244 ± 681 grams. Preterm delivery before 37 and 34 weeks' gestation was observed in 9% and 3% of patients, respectively. Fetal growth restriction was observed in three cases (9%) and there was only one case (3%) of preeclampsia.
Conclusions: Behcet's Disease is not associated with unfavorable pregnancy outcomes in most of the cases. Disease is in remission in most of the cases. Adverse effects of the medications used to treat Behcet's Disease were not observed. Hence, Behcet's Disease affect women of childbearing age, it will continue to be an issue in pregnancy. Large prospective cohort studies are needed to determine the pregnancy outcomes in Behcet's Disease.
Key words: Behcet's Disease, pregnancy, vasculitis
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