Abstract

The study assessed the effectiveness of a novel collagen builder formulation in enhancing collagen synthesis in human dermal fibroblasts, comparing it to commercial hydrolyzed collagen products. Dermal fibroblasts are vital for skin health as they produce collagen, maintaining skin elasticity and strength. The new formulation combines amino acids, vitamins, and active ingredients from specific plant extracts to boost collagen production. In vitro experiments showed that this formulation increased collagen synthesis by approximately 250% compared to vitamin C and outperformed bovine and marine collagen products by 3.24 and 1.66 times, respectively and 4.19 times better than the plant collagen booster product, at a 2.5 mg/mL concentration. Overall, the preliminary findings suggest that this novel formulation could serve as an advanced treatment for skin health and anti-aging, although comprehensive molecular analyses, in vivo studies, and clinical trials are required for validation.

Key words: Collagen booster, Nutraceutical, Skin health, Sustainable, Plant-based