Objective: To compare protective efficacy of cinnamon extract and green tea against Bisphenol A induced
histological changes in rat kidney.
Study Design: Randomized control trial.
Place and Duration of Study: The study was conducted at animal house of national institute of health sciences,
th th Islamabad from 16 September 2016 to 16 March 2017.
Materials and Methods: Sixty adult male Sprague Dawley rats were placed in 4 confines having 15 rats each.
Rats in control group A were given distilled water subcutaneously for 30 days. Rats in experimental group B
were given Bisphenol a (BPA) s/c at dose of 30mg/kg/day for 30 days. Rats in group C were given cinnamon
(200mg/kg/day) orally along with s/c injection of BPA while group D rats received green tea orally along with s/c
BPA injections. Dissection was done after 30 days and right kidney of all rats were dissected out and examined
grossly for weight and appearance and histologically for changes in glomerulus and Bowman's capsule. Data
was entered and analyzed in SPSS version 22. Mean and standard error was calculated for the quantitative
variables. Categorical variables were presented by frequency and percentage.
One way analysis of variance (ANOVA) was applied for the mean comparison of quantitative variables between
control and experimental groups. Post hoc tuckey's test was applied for the multiple comparisons among
Chi square test was applied for the comparison of qualitative variables among groups. A p value less than 0.05
was considered as a significant value.
Results: Gross and histological parameters were observed in experimental and control groups. Deterioration
of kidney structure was greatest in group B as compared to control group. Although both group C and D
protected kidney against these changes but group D offered more nephron protection than group C.
Conclusion: BPA adversely affects morphology and microstructure of kidneys by causing oxidative stress and
green tea is more beneficial than cinnamon in ameliorating these nephrotoxic effects of BPA.
Bisphenol A, Cinnamomum Zeylanicum, Kidney, Oxidative Stress
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