Abstract

Growing interest in transforming agro-industrial waste into health products drives this study, aligning with Sustainable Development Goal (SDG) 12: Responsible Consumption and Production. We investigated Cleistocalyx nervosum var. paniala (C. nervosum or Makiang in Thai) seed waste extract, recognized for its biological and antioxidant properties. Its influence on lipid metabolism, liver function enzymes, and pro-inflammatory markers, including interleukin-6 (IL-6), and oxidative stress, was examined in high-fat diet (HFD) fed rats. In vitro analysis confirmed the phytochemical content and antioxidant activity of C. nervosum seed extract. In vivo, HFD feeding successfully induced hyperlipidemia, elevated liver enzymes, increased serum IL-6, and hepatic oxidative stress. Notably, oral administration of C. nervosum seed extract (125, 250, and 500 mg/kg for 4 weeks) significantly mitigated these effects, highlighting its therapeutic potential for dyslipidemia. The favorable outcomes are presumed to stem from bioactive compounds that lower lipid concentrations, suppress IL-6, and attenuate oxidative damage in the liver by minimizing lipid peroxidation, stimulating antioxidant enzymes, and promoting hepatic function. This research underscores the value of C. nervosum seed extract as a promising novel supplement for dyslipidemia, contributing to SDG 3: Good Health and Well-being by offering a natural approach to non-communicable disease management while promoting a circular economy through waste valorization.

Key words: Cleistocalyx nervosum var. paniala, hyperlipidemia, antioxidants, lipid-lowering effects, liver enzymes.