Abstract

Backgroud: Isoflavone compounds in soy are known as phytoestrogen compounds. These compounds are expected to have important roles in replacing estrogen role in menopausal women. Aim: The purposes of this study were to investigate the estrogen receptor modulation by soy isoflavone compounds and how the estrogen compound takes a role in gene synthesis related to proliferation and apoptosis. Methods: The analysis was performed in silico manner in which docking as the most important method was carried out using Hex 8.0 software and HADDOCK webserver. Interaction analysis was then done to observe the interactions between soy isoflavone compound and several related proteins using the softwares of Discovery studio, LigPlus, and NUCPLOT. Results: The results of this study indicated that soy isoflavone compound have the ability to bind to estrogen receptors.Conclusions: it can be concluded that soy isoflavone compounds can serve as phytoestrogen that can activate estrogen receptor.

Key words: daidzein; estrogen; estrogen receptor; genistein; glycitein; in silico.