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Biomed Res Ther. 2017; 4(5): 1327-1340

Comparison of the predictive value of prooxidant-antioxidant balance and heat shock proteins in the diagnosis of neonatal asphyxia

Hassan Boskabadi, Gholamali Maamouri, Majid Ghayour-Mobarhan, Fatemeh Bagheri, Maryam Zakerihamidi, Maryam Kalate Mollaey, Elahe abbasi, Afsaneh zareh, Akram Tamannanlo.


Introduction: Asphyxia is one of the important cause of infants' mortality. Accurate and early diagnosis of asphyxia has an important role in performing appropriate protective treatment protocol; therefore, we compared the diagnostic value of two methods of Prooxidant-Antioxidant Balance (PAB) and Heat shock proteins 70 (HSP70) among healthy term infants and neonates with asphyxia. Methods: In this prospective case- control study, we compared the diagnostic value of two methods of PAB and HSP70 in healthy term infants (N=38) and Neonates with asphyxia (N=30) in Mashhad Ghaem hospital from 2011 to 2015. The diagnostic value of HSP70 and PAB was compared with statistical tests of Chi-square, T-Test, Man-Whitney, Roc curve and regression models. Results: The newborns in two groups were significantly different in terms of the first (P=0.000) and fifth minute Apgar score (P=0.000), HSP70 (P=0.000), PAB (P=0.000), PH (P=0.000), BE (P=0.000) and HCO3 (P=0.015). HSP>0.218 ng/dl has 60% sensitivity and 76% specificity for the diagnosis of asphyxia while PAB>11.3 HK has 84% sensitivity and 92% specificity for the diagnosis of asphyxia.Conclusion: According to the results of this study, HSP70>0.22 ng/dl and PAB>11.3 HK Unite can be used as biochemical markers for the diagnosis of perinatal asphyxia (P=0.001). The sensitivity and specificity of PAB in the diagnosis of asphyxia is higher than HSP70 and simultaneous measurement of these two markers can correctly diagnose 84% of asphyxia cases.

Key words: Asphyxia, Heat shock proteins (HSPs), Neonate, Prooxidant-Antioxidant Balance (PAB)

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