Home|Journals|Articles by Year|Audio Abstracts RSS - TOC

The efficacy and safety of clonidine and dexmedetomidine as an adjuvant in supraclavicular brachial plexus block for elective upper limb surgery

Yogesh Tilkar, Sangeeta Bansal Agarwal, Rahul Gupta, Sanjeevani Karmalkar, Prabha Khatri, Neetu Gupta.


Background: Adjuvant play very important role in regional anesthesia and search for better adjuvant is still going on.

Objectives: The objectives of this study are to find equipotent doses and to compare the efficacy of two α2 agonists clonidine and dexmedetomidine as an adjuvant in supraclavicular block.

Materials and Methods: A total of 90 patients of the American Society of Anaesthesiologists 1 and 11 of age 20-50 years undergoing elective upper limb surgeries under supraclavicular block divided into three groups: Group N: Received injection bupivacaine 0.5% 15 ml + injection. Lignocaine with adrenaline 2% 15 ml + normal saline 0.5 ml. Group D: 1 μg/kg dexmedetomidine. Group C: 1.5 μg/kg clonidine as studied drug in place of normal saline. Onset, duration of sensory and motor block, duration of analgesia, visual analog scale (VAS) score, hemodynamics, sedation, and other side-effects noted down.

Results: Onset of sensory and motor block in Group D (8.13 ± 2.52 and 12.13 ± 2.90), Group C (7.97 ± 2.58 and 12.47 ± 2.89), and Group N (12.43 ± 2.57 and 17.97 ± 3.06) groups, respectively. Duration of sensory and motor block was 528.2 ± 105.27 and 464.17 ± 93.15 in Group D, 544.97 ± 113.51 and 476.57 ± 105.41 in Group C, and 292 ± 77.4 and 257 ± 75.63 in Group N, respectively. Duration of analgesia was 644.93 ± 118.45 in Group D and 646.93 ± 112.18 in Group C and 352.6 ± 84.39 in Group N. Both studied groups were comparable to each other in above parameters and are significantly better than Group N. VAS score in the post-operative period at 360 min was higher in Group N (5.12 ± 0.68) when compared to Group C (4.5 ± 0.73) and Group D (2.07 ± 0.94), respectively.

Conclusion: Dexmedetomidine and clonidine as an adjuvant to supraclavicular block were found equipotent in the studied doses. However, post-operative VAS was found low in dexmedetomidine group.

Key words: Clonidine; Dexmedetomidine; Supraclavicular Block

Full-text options

Share this Article

Online Article Submission
• ejmanager.com

ejPort - eJManager.com
Review(er)s Central
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.