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Review Article

SRP. 2021; 12(1): 49-54


The Role of Innate Immune Response And IL-6 IN Osteoarthritis Patients in Basrah Province

Raghed M. Jassem, Dalia Mohammed, Hiba Abdelmageed Younis, Muhannad Maki Abdul Kareem, Israa S. Salman.

Abstract
Background: Osteoarthritis (OA) has been observed as degeneration disease of joint cartilage and the underlying bone affecting millions of people worldwide. OA has traditionally been classified as a non-inflammatory arthritis but with evidences accumulation indicates the role of immune response and inflammation in OA onset and progression.
Aim of study: To shed the light on role of innate immune response, CRP and IL-6 level in the development of OA in Basra province.
Patients and methods: 55 osteoarthritis patients (11 males and 44 females) and 70 healthy individuals as control (24 males and 46 females) were participate in this study. Total and differential WBCs count in whole blood in addition to the levels of all ESR, CRP and IL-6 were measured in serum for all participants.
Results: The results were recorded a significant increasing in total WBCs count, neutrophils and monocyte in addition to the level of all inflammatory markers (ESR, CRP and IL-6) in osteoarthritis patients as compared with healthy control. While lymphocytes and platelets count record an increase in OA patients but insignificant . A significant positive correlation was found between IL-6 level in serum and each of CRP, ESR, WBCs and the platelet. In addition to a significant correlation was found between CRP and both of WBCs and ESR.
Conclusion: The results indicates the active participation of inflammatory response in development of osteoarthritis in addition to the importance role for IL-6 as considered multifunctional cytokines effect different immunological parameters in the body and has adverse effect in development of OA.

Key words: Osteoarthritis, inflammatory response, CRP, ESR, IL-6






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The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.