Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles
 

Open Access

Original Article

AJVS. 2017; 55(2): 77-82


Hematocytological Evaluation of Hydroxyurea-Induced Toxicity in Male Rats

Asmaa M. Khamis, Samah S. Oda, Asmaa F. Khafaga, Mohamed A. Hashem.

Abstract
The toxicity of hydroxyurea (HU), a treatment for specific neoplasms, sickle-cell disease, polycythemia vera and thrombocytosis was assessed in rats. Forty rats were divided equally into four groups. The first group was kept as control and received only purified water, the second group (HU250) orally administered hydroxyurea 250 mg/kg b.wt/day, the third group (HU500) administered hydroxyurea 500 mg/kg b.wt/day and the fourth group (HU750) administered hydroxyurea 750 mg/kg b.wt/day. The treatment was continued for 20 days. The evaluated parameters were assessed after 10 and 20 days of the experiment. Results revealed decrease in body weight in all treated groups. In addition, decreased circulating leukocytes, erythrocytes and platelets with decreased bone marrow cellularity were evident in all treated groups with different degree of severity. Moreover, aplastic anemia associated with marked severe hypocellularity of bone marrow was detected in HU500 and HU750 groups on the second period of the experiment. It could be concluded that hydroxyurea administration induced hematopoietic and bone marrow toxicity in rats.

Key words: hydroxyurea, bone marrow, aplastic anemia, hematology.



Share this Article


Advertisement
Oxidants and Antioxidants in Medical Science

SUBMIT YOUR ARTICLE NOW


ScopeMed.com
BiblioMed Home
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.