Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles
 

Open Access

Original Research



The influence of carrageenan on markers of endogenous intoxication in rats

Mariya Marushchak, Inna Krynytska, Oksana Kopanytsia, Larysa Tupol, Iryna Savchenko, Lyudmyla Mazur.

Abstract
Background: The growth of the world population and the need to increase food production led to the widespread use of food additives. One of such additives is carrageenan. Potentially negative health effects of carrageenans prompt us to question safety of their widespread use.

Aims and Objectives: In this study, we defined the effect of carrageenan (E407) consumption on the main markers of endogenous intoxication in rats.

Materials and Methods: Experimental studies were conducted on 72 non-linear, female, white rats weighing 150-180 g. The experimental animals had free access to 0.5% carrageenan solution in drinking water. Control group of animals received pure water. Syndrome of endogenous intoxication was evaluated using measurements of low, medium, and high molecular weight substances in blood plasma, red blood cell suspension, and urine.

Results: Our results indicate shift of the markers of intoxication syndrome toward mainly catabolic substances. The results obtained after 1 week of the experiment correspond with phase of partial compensation, characterized by increased concentrations of low and middle molecular weight substances in red blood cells and plasma. After 2 weeks and up to 1 month of the experiment, the predominantly catabolic markers of endogenous intoxication continue to increase in erythrocytes and plasma, indicating a shift to the phase of partial decompensation to systems and organs of detoxification.

Conclusion: The consumption of carrageenan with drinking water in concentration of 0.5% was associated with the development of excessive levels of low and middle molecular weight substances with reduced ability of kidneys to excrete toxic products.

Key words: Carrageenan; Endogenous Intoxication; Rats



Similar Articles

Guiding RNAi Design Through Characterization of Endogenous Small RNA Pathways.
Peter JO, Santos-Ortega Y, Flynt A
Methods in molecular biology (Clifton, N.J.). 2022; 2360(): 33-47

A flexible electrode array for determining regions of motor function activated by epidural spinal cord stimulation in rats with spinal cord injury.
Mao GW, Zhang JJ, Su H, Zhou ZJ, Zhu LS, Lü XY, Wang ZG
Neural regeneration research. 2022; 17(3): 601-607

Biomimetic chitosan scaffolds with long-term controlled release of nerve growth factor repairs 20-mm-long sciatic nerve defects in rats.
Liu FD, Duan HM, Hao F, Zhao W, Gao YD, Hao P, Yang ZY, Li XG
Neural regeneration research. 2022; 17(5): 1146-1155

HOXA11-AS aggravates microglia-induced neuroinflammation after traumatic brain injury.
Li XL, Wang B, Yang FB, Chen LG, You J
Neural regeneration research. 2022; 17(5): 1096-1105

Endogenous miRNA Sponges.
Alkan AH, Akgül B
Methods in molecular biology (Clifton, N.J.). 2022; 2257(): 91-104


Full-text options


Latest Statistics about COVID-19
• pubstat.org


Add your Article(s) to Indexes
• citeindex.org






Covid-19 Trends and Statistics
ScopeMed.com
CiteIndex.org
CancerLine
FoodsLine
PhytoMedline
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.



ScopeMed Web Sites