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Effect of fermented red bean extract (Phaseolus vulgaris L.) on spermatogenic cells in mice exposed to smokeElias Setyo Novanto, Aswin Rafif Khairullah, Budiarto Budiarto, Tita Damayanti Lestari, Sri Pantja Madyawati, Tatik Hernawati, Kadek Rachmawati, Imam Mustofa, Siti Darodjah Rasad, Ahmed Qasim Dawood, Ginta Riady, Wasito Wasito, Riza Zainuddin Ahmad, Bima Putra Pratama, Novia Chairuman. Abstract |  Download PDF | Cited by 0 Articles |  Post | Background:
Red beans are known to be rich in bioactive compounds such as flavonoids, anthocyanins, tannins, and polyphenols that have high antioxidant activity so that they are believed to be able to provide protection against testicular tissue exposed to toxic substances, including cigarette smoke.
Aim:
This study aims to scientifically analyze the effect of administering fermented red bean extract on the number of spermatogenic cells in male mice exposed to cigarette smoke.
Methods:
This experimental study used 25 mice. Group K (–) was given 0.5 mL of 1% CMC-Na, group K (+) was given 0.5 mL of 1% CMC-Na and exposed to cigarette smoke, groups P1, P2, and P3 were given fermented red bean extract (Phaseolus vulgaris L.) with doses of 26 mg/kgBW, 52 mg/kgBW, 104 mg/kgBW and exposed to cigarette smoke, respectively. Each group was given one cigarette a day for 36 days. Testicular histopathology preparations were made with HE staining and continued with spermatogenic cell counting. Data were analyzed using One Way ANOVA and continued with Duncan's test (p
Key words: Health risks; Red beans; Spermatogonium; Spermatocytes; Spermatids.
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