Home|Journals Follow on Twitter| Subscribe to List

Directory for Medical Articles
 

Open Access

Original Article

J App Pharm Sci. 2017; 7(9): 199-206


In Vitro Antioxidant Activity and Hepatoprotective Potential of Ceropegia spiralis Against Paracetamol Induced liver injury

Rajkiran Kolakota, R. Santosh Kumar, Sunil Kumar Patnaik.

Abstract
Ceropegia spiralis is a usually used remedial herb in herbal remedies to delight diverse diseases. The plan of the current investigation is to assess the in vitro free radical scavenging activity and hepatoprotective activity of Ceropegia spiralis against paracetamol induced liver damage in preventive and curative models. The Ceropegia spiralis was evaluated for in vitro antioxidant activity by 2, 2-diphenyl-1-picryl hydrazyl (DPPH), hydroxyl and superoxide radical scavenging activity and inhibition of lipid peroxide and ascorbic acid was used as a standard. In two separate studies, the 100, 200 and 400 mg/kg body weight of Ceropegia spiralis extract, and 100 mg/kg body weight of Silymarin in both studies were given orally. The hepatic damage was done by oral administration of 2 g/kg body weight of paracetamol. The IC50 values of Ceropegia spiralis in the superoxide, 2, 2-diphenyl-1-picryl hydrazyl (DPPH), hydroxyl radical scavenging activity and inhibition of lipid peroxidation was found to be 365.64, 381.13, 461.32 and 469.39 μg/ml correspondingly. The hepatic damage in rats induced by paracetamol as evidence by elevated serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and total bilirubin levels and decreased serum total proteins. The administration of Ceropegia spiralis and Silymarin in both preventive and curative models decreases the toxic effect of paracetamol on the above selected serum parameters.

Key words: Ceropegia spiralis, Antioxidant, Paracetamol, Hepatoprotective, Rat.



Share this Article


Advertisement
Journal of Environmental and Occupational Science

SUBMIT YOUR ARTICLE NOW


ScopeMed.com
BiblioMed Home
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.