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RMJ. 2017; 42(4): 467-470

Lipid profile abnormalities in Type II diabetics with and without microalbuminura

Abdul Qadoos, Qurat ul Ain Javaid, Anjum Shahzad, Israr Toor.

Objective: To find the frequency of microalbuminemia in type II diabetic patients and to determine the frequency of different abnormalities of lipid profile in Type II diabetic patients with and without microalbuminuria.
Methodology: Total 344 patients of type-II diabetes mellitus of both genders between the age of 35-70 years were enrolled in the study from Lahore General Hospital, Lahore, Pakistan. Blood sample for lipid profile was collected after 12 hours of fasting and spot mid stream early morning urine sample was collected in laboratory for microalbuminuria detection.
Results: Out of 344 cases, 151 (43.90%) were male and 193 (56.10%) were females with male to female ratio of 2:1. 132 (38.37%) cases were between 35-50 years of age while 212 (61.63%) between 51-70 years of age (mean 53.18+9.32). Frequency of microalbuminuria was recorded in 32.56% (n=112) cases. Out of 112 cases of microalbuminuria, Hypertriglyceridemia was seen in 98 (87.5%) cases, increased LDL-C in 102 (91%) while decreased HDL-C was found in 95 (84.8%) cases (p=0.000). Out of 232 cases of without microalbuminuria, hypertriglyceridemia was found in 143 (61%) cases, increased LDL-C in 151 (65%) and decreased HDL-C was seen in 169 (72.8%) cases. Frequency of microalbuminuria was seen more in age group of 51-75 years (n=65) with disease duration of more than 3 years (n=71), HbA1c ≥6 (n=69) and BMI more than 30.
Conclusion: The frequency of hypertriglyceridemia, increased LDL-C and decreased HDL-C is higher in type II diabetic patients with microalbuminuria as compare to patients without microalbuminuria and is dependent on advanced age, duration of disease and BMI.

Key words: Type II diabetes, microalbuminuria, hypertriglyceridemias, increased LDL-C and decreased HDL-C.

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