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Original Research

RMJ. 2019; 44(2): 302-307


Efficacy of paliperidone palmitate on psychiatric symptoms and attitudes toward medication in schizophrenia

Bong Ju Lee.

Abstract
Objective: To examine the efficacy of once-monthly paliperidone palmitate (PP1M) on symptoms and attitudes toward medication in individuals with schizophrenia.
Methodology: Out of 52 subjects with schizophrenia, 43 were included in the study. The Positive and Negative Syndrome Scale (PANSS) and the ten-item Drug Attitude Inventory (DAI) were used to collect data. With a cut-off score of 4 on the DAI, subjects were divided into two groups: adherent and non-adherent. A paired t-test was also performed for comparison between two different assessment time points.
Results: During a 1-year study period with PP1M, both groups showed improvement in their symptoms. The change in DAI was significant and both groups showed improvement in DAI score. Subjects with a low DAI score at baseline showed shorter treatment duration compared with subjects with a higher score at baseline.
Conclusions: PP1M was effective in improving symptoms and positively changing attitudes toward medication in individuals with schizophrenia. Therefore, it may have promising effects cation in individuals with schizophrenia.

Key words: Schizophrenia, drug Attitude Inventory, paliperidone palmitate



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