Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles
 

Open Access

Review Article

Biomed Res Ther. 2017; 4(4): 1228-1245


Hearing impairments, presbycusis and the possible therapeutic interventions

Basharat Hussain, Muhammad Ali, Muhammad Qasim, Muhammad Shareef Masoud, Luqman Khan.

Abstract
The hearing is an important sensation of all living organism to maintain his or her life mainly in human. Any distortion to it leads to hearing impairment. Hearing loss (HL) can be congenital or acquired. It can be syndromic; HL associated with other abnormalities or non-syndromic, HL is not associated with any other anomalies. Hearing impairment have mostly autosomal recessive loci, but can be autosomal dominant, X-linked, and mitochondrial. Acquired HL can be genetic or environmental factors based. Age-related HL is acquired hearing loss occur in aged population. Its prevalence rate increases with age. Genetic of presbycusis is not well-known, but NAT2*6A polymorphism, SNPs in KCNQ4, grainy head-like 2 gene, Glutamate receptor-7 gene, 4977-bp mt-DNA deletion in human and 4834-bp mtDNA deletion in rodents were identified. Different strains of mice are developed like C57BL/6J, CBA/CaJ, DBA/2J, BALB/cJ and Fisher 344 albino rats mainly used as models to study HL and presbycusis. Like other disorders have complete treatment, but HL cannot be completely treated. However some attempts can be made for its betterment by using hearing aid devices, surgical and pharmaceutical treatments. In future stem cells and gene therapy will be the affective methods to treat congenital hearing impairment and presbycusis.

Key words: Hearing Loss, Prevalence, Factors, Presbycusis Genetics, Animal models, Treatments



Similar Articles

Presenilin mutations and their impact on neuronal differentiation in Alzheimer's disease.
Hernandez-Sapiens MA, Reza-Zaldívar EE, Márquez-Aguirre AL, Gómez-Pinedo U, Matias-Guiu J, Cevallos RR, Mateos-Díaz JC, Sánchez-González VJ, Canales-Aguirre AA
Neural regeneration research. 2022; 17(1): 31-37

Dendritic spine density changes and homeostatic synaptic scaling: a meta-analysis of animal studies.
Moulin TC, Rayêe D, Schiöth HB
Neural regeneration research. 2022; 17(1): 20-24

SYNGR4 and PLEKHB1 deregulation in motor neurons of amyotrophic lateral sclerosis models: potential contributions to pathobiology.
Marques RF, Duncan KE
Neural regeneration research. 2022; 17(2): 266-270

Transcranial magnetic stimulation in animal models of neurodegeneration.
Uzair M, Abualait T, Arshad M, Yoo WK, Mir A, Bunyan RF, Bashir S
Neural regeneration research. 2022; 17(2): 251-265

extract promotes M2 polarization and reduces oligomeric amyloid-β-induced inflammatory reactions in microglial cells.
Sun ZQ, Liu JF, Luo W, Wong CH, So KF, Hu Y, Chiu K
Neural regeneration research. 2022; 17(1): 203-209


Full-text options


Add your Article(s) to Indexes
• citeindex.org






ScopeMed.com
CiteIndex.org
CancerLine
FoodsLine
PhytoMedline
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.