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Hematological Changes And Tissue Biochemical Profile In Doxorubicin Induced Testicular Toxicity And Its Amelioration With Quercetin in Male Albino Wistar Rats

S.Divya, D. Madhuri, M. Lakshman, A. Gopal Reddy.




Abstract

Study was conducted to evaluate hematological and tissue biochemical profile in doxorubicin induced testicular toxicity and its amelioration by quercetin. A total of 48 male albino rats (Wistar strain) were randomly divided into 4 groups consisting of 12 in each group. Group 1-Control, Group 2-Doxorubicin treated @4mg/kg b.wt intraperitoneally weekly once. Group 3-treated with quercetin @ 80mg/kg b.wt, orally daily. Group 4-treated with doxorubicin @ 4 mg/kg b.wt, intraperitoneally weekly once and quercetin @ 80mg/kg b.wt, orally daily. Hematological studies revealed that overall mean values of PCV, Hb, TEC, TLC were significantly (P

Key words: Rats, Doxorubicin, Quercetin, hematological changes, tissue oxidant profile






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