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Hypoglycemic and Hypolipidemic Effect of Methanol Extract of Hibiscus Sabdariffa Seed in Alloxan Induced Diabetic Albino Rats

F. S. Adefolalu, J. S. Salawa, T. Y. Gara and A. N. Abubakar.


This study investigated the hypoglycemic and hypolipidemic effect of the oral administration of methanol extract of Hibiscus sabdariffa seed in alloxan induced diabetic albino rats. Two different doses (200 and 400 mg/kg) of the methanol extract of Hibiscus sabdariffa seed was administered daily to two groups of diabetic rats for a period of two weeks. Metformin (250 mg/kg) was given as the reference standard drug. Phytochemical, acute toxicity, fasting blood glucose, body weight, cholesterol, triglyceride and lipoproteins levels were determined using standard methods. Acute toxicity of methanol extract of Hibiscus sabdariffa seed was estimated to be greater than 5000 mg/kg body weight. There was an initial decrease in the body weight of the experimental animals after induction of diabetes but increased significantly (p

Key words: Hypoglycemic, hypolipidemic, Alloxan, phytochemical, Hibiscus sabdariffa

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