The present study was designed to investigate the adverse effects of aluminum chloride hexahydrate on the heart, liver and kidneys of rabbits. Twenty-four apparently healthy male and female rabbits were randomly assigned to four groups. The two control groups male (n= 6) and female (n= 6) received subcutaneous injections of physiological saline. The other two Al-treated groups of male (n= 6) and female (n= 6) were given 2.5mg/kg B.W. S/C five times per week for 3 months. At the 6th weeks and the 12th weeks, three rabbits from each group were necropsied and tissues specimens from heart, liver and kidneys were collected and processed for the following histopathologic examination. The heart of both sexes of intoxicated rabbits showed congestion of blood vessels, interfibrillar edema, hemorrhage as well as Zenker's degeneration and necrosis of myocardium. The Liver showed periportal edema, mild fibroplasia, infiltration of inflammatory cells, adenomatous and papillary hyperplasia of bile ductules. The encountered lesions of the kidneys were in the form of vacuolations and necrosis of renal tubular epithelium, with intratubular necrotic cellular debris and hyaline casts. An additional lesion of severe interstitial nephritis was also seen in some areas. It was concluded that the adverse toxic effects of aluminum chloride were time-dependent manner on heart, kidneys and liver of of both sexes of rabbits.
aluminum chloride, rabbits, heart, liver, kidneys, Zenker's degeneration.
coinfection as source of pyogenic liver abscess.
Burch J, Tatineni S, Enofe I, Laird-Fick H
BMJ case reports. 2021; 14(5):
Hepatitis C virus eradication decreases the risks of liver cirrhosis and cirrhosis-related complications (T-COACH).
Hsu WF, Tsai PC, Chen CY, Tseng KC, Lai HC, Kuo HT, Hung CH, Tung SY, Wang JH, Chen JJ, Lee PL, Chien RN, Lin CY, Yang CC, Lo GH, Tai CM, Lin CW, Kao JH, Liu CJ, Liu CH, Yan SL, Bair MJ, Su WW, Chu CH, Chen CJ, Lo CC, Cheng PN, Chiu YC, Wang CC, Cheng JS, Tsai WL, Lin HC, Huang YH, Huang JF, Dai CY, Chuang WL, Yu ML, Peng CY
Journal of gastroenterology and hepatology. 2021; ():
Stent-free duct-to-duct biliary reconstruction after hepatectomy for liver tumors involving biliary confluence at the hepatic hilum: a monocentric experience.
Del Fabbro D, Cimino MM, Procopio F, Torzilli G
Updates in surgery. 2021; ():
Remote organ ischaemic preconditioning in human recipients suppresses systemic inflammation and prevents glycocalyx degradation in living-donor liver transplantation: A randomised controlled trial.
Tosun M, Guner Can M, Aksu U, Emiroglu R, Toraman F
European journal of anaesthesiology. 2021; 38(6): 667-669
Acute renal injury due to rhabdomyolysis: A tertiary hospital experiencee
Esref Arac, Ihsan Solmaz, Enver Yuksel, Nazim Ekin, Songul Arac
Annals of Medical Research. 2021; 28(2): 253-7